Immune system

William Ludwig was a 64-year-old retired corrections officer living in Bridgeton, New Jersey, in 2010, when he received a near-hopeless cancer prognosis. The Abramson Cancer Center at the University of Pennsylvania had run out of chemotherapeutic options, and Ludwig was disqualified from most clinical trials since he had three cancers at once—leukemia, lymphoma, and squamous […]

Some cancer therapies focus the attention of the immune system like a spotlight over Hollywood.Everett Collection / Shutterstock In early May, 1891, William Coley, a New York surgeon, had before him an interesting case. The patient, a 35-year-old Italian man, had sarcoma tumors in his neck and tonsils, and was slowly starving to death as […]

When talking about our health, we tend to refer breezily to “the immune system,” as if it were as simple as an electric fence keeping out invaders. And there’s certainly an electric fence component: The innate immune response is an ancient, relatively nonspecific kind of defense that triggers inflammation and the deployment of attack cells […]